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The pathophysiology of MASLD/MASH encompasses complex interactions among genetic background, impaired insulin signaling, hepatic lipid accumulation, inflammatory cascades, and progressive fibrosis
The effect of oxyntomodulin on body weight and BAT temperature is not evident in mice that lack the GLP-1R highlighting a GLP-1R dependent action
doi: 10.1111/dom.14110 152 WillmsBWernerJHolstJJOrskovCCreutzfeldtWNauckMA
& Skiniotis, G
Some of these proteins are also released by immune cells that are recruited to adipose tissue and participate in a feed forward loop for inflammation [19]
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