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This inconsistency highlights a blind spot in long-term obesity management as the benefits of GLP-1RAs risk being negated by subsequent weight regain
Publication-quality figures, LaTeX-typeset PDF, structured data files, and automated peer review
Gatto L et al
The majority of intracellular proteins are degraded by the ubiquitinproteasome system (UPS), a multi-enzyme process that involves the covalent conjugation of ubiquitin to a substrate protein and its recognition and degradation by the core multicomponent proteolytic complex of the UPS, the proteasome
63 In addition to their benefits on quality of life in HFpEF, further randomised trials are needed to effectively assess the effects of GLP-1 RA on harder clinical outcomes
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