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2020 Dec 17;21(24):9646
NICE recommends disease-modifying antirheumatic drugs (DMARDs) such as methotrexate as first-line treatment, with biologic therapies (TNF inhibitors, IL-6 inhibitors) or JAK inhibitors for patients with inadequate response
Several mechanisms contribute
Liu H, Guo X, Chu Y, Lu S
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In a meta-analysis of 60 studies involving 60,077 T2D patients, GLP-1RAs marginally reduced the UACR in comparison to placebo and other antidiabetic agents, but resulted in no clinically relevant changes in eGFR ( Renoprotective Mechanisms of GLP-1RAs Experimental studies to elucidate the beneficial effects on DKD have been extensively reported
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