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There is no documented contraindication, but the combination has not been studied in clinical trials

For people who dont absorb B12 well, or those whose want to make sure beyond reasonable doubt that theyre getting an ample dose quickly, B12 shots are available via prescription, says Richard Foxx, M.D., a board-certified physician who treats hormonal disorders and nutritional deficiencies

Caption: Entry points for ozone therapy in the dysfunctions affecting CFS patients

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Research on neurotransmitter-system interactions has also been compiled in recent reviews, broadening the picture beyond the classical angiogenic and gastric framings (PMID 38675421)

Side Effects: Generally well tolerated in research settings