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Proteolytic clearance (no CYP450), no major pharmacokinetic interactions expected

Stability can be affected by formulation, storage, heat and oxidation

Nonetheless, for completeness and interpretive purposes, studies using animal models are included in this review and are explicitly described as such herein

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PMID 17584759

Gradually heating the mixture on a water bath under stirring, so bringing the temperature up to 98C at the end of about 3 hours, 9 cc of water was added