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They electrically stimulated the intralaminar thalamic area of rabbits to induce sleep, collected the cerebral venous blood via extracorporeal dialysis, and fractionated the dialysate hunting for the substance responsible
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Free Radic Biol Med 15: 195202
According to Wegovy's prescribing information, clinical trials have shown that 30% of patients experience diarrhea on the drug (compared to 16% of people on a placebo) and 24% experience constipation (compared to 11% on placebo)
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This warning is based on rodent studies showing increased risk, although no clear link has been found in humans
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