Epinephrine acts through erythroid signaling pathways to activate sickle cell adhesion to endothelium via LW-v3 interactions
Tryptophan is especially sensitive to light
(ref) Seiwerth S, Milavic M, Vukojevic J, Gojkovic S, Krezic I, Vuletic LB, Pavlov KH, Petrovic A, Sikiric S, Vranes H, Prtoric A, Zizek H, Durasin T, Dobric I, Staresinic M, Strbe S, Knezevic M, Sola M, Kokot A, Sever M, Lovric E, Skrtic A, Blagaic AB, Sikiric P
In the mouse model of STZ-induced DKD, proximal tubule-specific knockout of Atg5 aggravates tubule injury and kidney damage, reflected as defective autophagy sensitized proximal TECs to ferroptosis (79)
Checklist for adherence: baseline labs, informed consent, dosing log, adverse event log, follow-up schedule, and stop criteria
Human pharmacokinetic data (Frieboes et al