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It will be difficult to engineer balanced agonism into a single small-molecule because the sequence hybridisation of the dual and triple peptide agonists has no obvious chemical analogue

No tolerance developed to this protective effect, which appeared to be mediated by (1) the activation of 5-HT 1A receptors, as it was antagonized by the administration of WAY100635 30 min before stress exposure

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Pancreatic -cell GLP-1 receptor agonism leads to glucose-dependent release of insulin, but this does not solely account for its ability to decrease postprandial glucose concentrations