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[60] Low muscle tone (hypotonia) can be a sign of many underlying conditions, including vitamin deficiencies (B1 and other B vitamins), hypothyroidism, carnitine deficiency, creatine deficiency, and methylation issues, as well as genetic conditions (of which there are hundreds)

Some patients benefit from longer-term treatment, while others transition to maintenance strategies after reaching their target weight

Mechanism study: By activating the PI3K/Akt pathway, inhibiting GSK-3 activity, and reducing tau protein hyperphosphorylation

10.1038/onc.2017.11 Oncogene 9 BrintonL

Y., Gauffre, F., Phi, T