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Clear instructions, reliable sourcing, and clinical oversight are essential

In the REDEFINE 1 trial, only 1% of participants discontinued treatment due to adverse events

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It is a dual agonist that activates both GLP-1 receptors and GIP (glucose-dependent insulinotropic polypeptide) receptors

While uncomfortable, increased cold sensitivity is generally a physiological adaptation to weight loss rather than a concerning adverse reaction

Another limitation is that we did not directly measure body length of wild-type and MC4R KO mice