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There also seems to be a class effect for long-acting GLP-1RAs with regard to improving cardiovascular outcomes, and it seems likely that this class of agents confers benefits by mechanisms that are different from both pioglitazone and SGLT2 inhibitors
Foley V et al
Park KY, Ko EJ, Kim IS, et al
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GSH activity is facilitated by activation of the Kelch-like ECH-associated protein 1 (Keap1)-Nuclear factor erythroid 2-related factor 2 (Nrf2)-antioxidant response element (ARE) redox regulator pathway, releasing Nrf2 that regulates expression of genes controlling antioxidant, inflammatory and immune system responses
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