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First, a bacterial reverse mutation test (Ames test) assessed AOD9604s mutagenic potential using four histidine-dependent auxotrophic mutants of Salmonella typhimurium (TA1535, TA1537, TA98, TA100) and one tryptophan-dependent auxotrophic mutant of Escherichia coli (WP2 uvrA), using both plate incorporation and pre-incubation methods at doses of 0, 1.6, 8, 40, 200, 1,000, and 2,000 g AOD9604/plate

PubMed laboratory research record [PMID: 41070406] PubMed record related to this compound for laboratory literature review

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These agents mimic the action of naturally occurring GLP-1, an incretin hormone produced by intestinal L-cells in response to food intake

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These results suggest that GLP-1 secretion depends primarily on Gs-EPAC signals in GLUTag cells