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PMID 12366374

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Its important to emphasize that much of this research is still in its early stages, and more robust human trials are needed to confirm these potential mental health benefits

In 2023 the firm abandoned development of lotiglipron after trial participants showed elevated liver enzymes, and the same year discontinued a twice-daily danuglipron dosing regime after almost three quarters of treated patients experienced nausea, while almost a half developed vomiting and a quarter diarrhoea

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This is likely due to temporary hair loss triggered by significant bodily changes, such as rapid weight loss or nutritional deficiencies