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The effect of antagonizing SSTR2a and SSTR5a on glucose-induced GLP-1 and SS secretion was investigated in the proximal perfused mouse intestine and their effects on glucose tolerance were evaluated in vivo
Obesity, insulin resistance and fatty liver may further amplify this cycle by increasing inflammatory signaling, altering bile-acid metabolism and reducing metabolic reserve
But since periods of fasting rarely occur on their own, we continually store that excess energy as an increasing body fat percentage
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The emerging role of FOXO transcription factors in pancreatic beta cells
