In the current perception, multiple-hit theory is the consensus on the pathogenesis of NAFLD (14, 15)
Angeli L, Morozova K, Scampicchio M
For biosimilar companies planning challenges to future reference biologics, the Humira case establishes the benchmark for pre-entry due diligence: mapping the entire secondary patent estate, identifying the subset most vulnerable to invalidity or non-infringement attack, and modeling the litigation cost and timeline against the expected commercial window under 180-day-equivalent market exclusivity
Important safety information includes a boxed warning for thyroid C-cell tumors and contraindication in patients with personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN2)
We demonstrated that the GSH increase in CO23RFLC conferred to this strain a clear advantage in counteracting oxidative toxic agents while assignment of other roles, such as a more efficient elimination of the drug from the cell, should be considered more speculative
A structural domain (the lid) found in pancreatic lipases is absent in the guinea pig (phospho)lipase