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And the research outcomes that depend on them
192-194 However, the combined effect of smoking and sleep apnea has been linked to worse cognitive impairment and metabolic parameters
The paper reports the absence of the positive effect under twice-daily dosing rather than a measured decrement, and no head-to-head statistical comparison of the two schedules is given but even read at its most conservative, that is not how a dose-dependent hypnotic behaves
Furthermore, metabolic synergy (protocooperation) enhances efficacy
And if twice-daily dosing failed to produce the effect that once-daily morning dosing did, the intuition that timing failures can be solved by adding another dose finds no support in the only data available
Smokers and Alcohol Abusers : These habits can also increase the risk of deficiency
