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Effective delivery systems are required for topical use

10.1007/s11010-005-5075-8 Mol

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For example, children ages 10 15 may produce 120 pg/ml, but adults by age 40 may only be producing 20 30 pg/ml.[ref] Suppression of melatonin by light: Even very low levels of light (1.5 lux) can suppress melatonin production