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According to the classic two-hits model, the increased insulin resistance, secondary to metabolic syndrome, determines an excessive lipid accumulation in healthy hepatocytes (first hit), mainly through an increased mobilization of free fatty acids from visceral adipose tissue to the liver

In this review, we discuss the advantages and offer an overview of the diverse range of documented side effects

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PubMed, Scopus, Embase, Web of Science and Cochrane Central library international databases were searched till September 2021