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The evaluation of GPx activity, glutathione reductase (GR), SOD, total serum antioxidant status (TAS), MDA and 8-OHdG in ALS patients, found a significant decrease in TAS levels and an increase of 8-OHdG and MDA levels, together with significantly higher oxidized/reduced glutathione (GSSG/GSH) ratio and IL-6 and IL-8 ( Antioxidants and Amyotrophic Lateral Sclerosis The evidence implicates free radicals and OS as factors related to the pathogenesis of ALS
Ubels JL, Clousing DP, Van Haitsma TA, et al
Bagherinia E, Falahi S, Mortazavi SH, Salari F, Rezaiemanesh A, Karaji AG
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Leeper NJ, Hunter AL, Cooke JP