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As a future direction, we propose testing whether, in the absence of Trim37 , PGCs progressively lose intrinsic germline determinants and fail to stabilize a coherent somatic identity because they do not receive appropriate lineage-specifying cues, ultimately resulting in elimination through cell death

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10.1210/10.1210/er.2006-0038 126 WangX.ZhouJ.DoyleM

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