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J Clin Anesth 2007;19:3703

The implementation of aerobic endurance training results in an elevation of shear stress and a chronic enhancement of flow-mediated stimuli, which in turn upregulate the expression of eNOS, increase capillary density, and augment mitochondrial oxidative capabilitytransformations that contribute to improved resting and exercise muscle perfusion as well as metabolic efficiency (76, 77)

Exosomes engineered to carry catalase were shown to mitigate neural inflammation and enhance neural viability in PD models [290]

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