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Anti-sense nucleotides (ASOs) have demonstrated promise in lowering RNA foci and their deleterious effects and ASOs are under clinical trials for ALS treatment ( 3.2 Alzheimer's disease (AD) AD is a progressive ND characterized by neurofibrillary tangles produced by tau proteins as well as a buildup of amyloid plaques ( However, recent investigations of alternative therapies for AD have sparked interest in compounds with disease-modifying capability, one such molecule, a natural polyphenol, is curcumin, which has anti-inflammatory and antioxidant properties (Table 1)

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Peroxisomes contain a wide range of flavoproteins or oxidoreductases enzymes namely Acyl-CoA oxidas, polyamine, oxidase D-aspartate oxidase, D-amino acid oxidase, L-pipecolic acid oxidase, L--hydroxyacid oxidase etc

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The catalytic tetrad formed by Sec, glutamine, tryptophan and asparagine is essential for GPx activity, since these residues are crucial for enzyme-substrate interaction and stabilization of the GSH-GPx interaction [47, 65, 66]

The Walled City's population increased dramatically following World War II, and by 1987 it had an estimated 33,000 residents within its 2.6-hectare (6+12-acre) borders, making it one of the most densely populated places on Earth at approximately 1.2 million inhabitants per square kilometre (3 million per square mile)