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In addition, the FSP1 protein contains an N-terminal myristylation sequence, and only myristylated FSP1 has anti-ferroptotic activity
Additionally, optimizing their targeting properties and conducting biosafety assessments are critical directions for achieving clinical translation
Manfridi A, Forloni GL, Arrigoni-Martelli E, Mancia M
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The pharmacokinetic profile (how long the peptide circulates) is entirely separate from the pharmacodynamic effect (how long melanin synthesis continues after receptor activation)
This is the most commonly reported side effect and is dose-dependent
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