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Through stable isotope tracing and chromatin-immunoprecipitation (ChIP) assay, we also found that ACTL6A promotes GSH synthesis by upregulating the rate-limiting enzyme GCLC as a co-transcription factor

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a separate Merck Phase 2b trial in hip-fracture patients (Adunsky et al., 2011, PMID 21067829) was stopped early after a cardiac safety signal emerged

GST-HDAC1 pull-down Approximately 1 g of GST or GST-HDAC1 protein bound to Glutathione Sepharose 4B beads was incubated with 1 g of purified His-C16orf87 protein in binding buffer (50 mM TrisHCl, pH 7.5, 100 mM NaCl, 10% glycerol, 0.5% NP-40, and 10 mM MgCl)

This article is intended to inform discussions within performance science and peptide research fields

doi: 10.1016/s2666-5247(23)00067-8 73 DarvishiE.OmidiM.BushehriA