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Since venetoclax and AZD-5991 rapidly induce apoptosis in CLL cells, these compounds were added in the last 24 hours of incubation to minimize single-drug cytotoxicity

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The introduction of new therapiesparticularly those with novel mechanisms of action or broader symptom coveragemay fragment prescriber preferences and intensify competition for patient share

Change history 21 September 2025 The original online version of this article was revised due to the figures 1, 2, 3 have been printed with a black background