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Phase IIB and IIA pharmacologic agents Key Point Only a small proportion of pharmacologic treatments evaluated in phase II progress to phase III and even fewer progress to market

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Questions that were rare even five years ago now surface at nearly every follow-up visit especially among patients who continue to struggle with inflammation, persistent bloating, metabolic syndrome , or weight-related hormonal changes , and in those who feel under-treated or unresponsive to standard medical therapy

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