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The most commonly reported side effects in clinical trials are gastrointestinal, including nausea, vomiting, diarrhoea, and constipation, which are typically most pronounced during the dose titration phase and tend to improve over time

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The OASIS program evaluated oral semaglutide 50 mg daily in adults with obesity and reported weight loss broadly comparable to the injectable 2.4 mg dose in the region of 15% of body weight