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Moreover, reducing tumor lactate levels inhibits Kla and disrupts the lactate metabolic balance in the TME, representing a promising cancer treatment option that has already been implemented in several preclinical and clinical trials
ThMP hydrolysis is known to be catalyzed by prostatic acid phosphatase ACP3, which is localized to plasmatic membrane and linked to the antinociceptive action of thiamine and its derivatives (130132)
Our methods consist of PubMed search of pertinent clinical trials and reviews until August 22, 2023 using the key words mentioned in previous section
Additionally, its effects on gut motility and bowel function mean it warrants caution in patients with bowel obstruction or severe gastrointestinal surgery history
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