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2b), with agonists that trigger robust receptor internalisation (GLP-1, exendin-4, exendin-D3) showing a stronger degree of GLP-1R-VAPB interaction compared to slow GLP-1R-internalising agonist exendin-F1

c The quality of evidence for this outcome was not classified as high due to heterogeneity deriving from the ELIXA, trial