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Several retrospective cohort studies have explored the association between the use of GLP-1RAs and the risk of intestinal obstruction compared to SGLT2 inhibitors in T2DM patients, with mixed outcomes

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GLP (glucagon-like peptide-1) receptor agonists are part of a class of drugs that were initially created to help address type 2 diabetes but are also now used for weight management purposes

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Ania Jastreboff, an obesity medicine physician scientist at Yale University School of Medicine/Yale School of Medicine, co-Director of the Yale Center for Weight Management and the lead author on the phase 2 study, said that the results were striking and concluded that Retatrutide holds promise for substantial weight reduction in adults with obesity over a 48-week period

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Understanding how each medication functions helps clarify why they can typically be used together safely

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