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Estrogen receptor beta ligand therapy activates PI3K/Akt/mTOR signaling in oligodendrocytes and promotes remyelination in a mouse model of multiple sclerosis
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Phase 3 trials can fail, and regulatory timelines extend
In addition, it has been described that oxidized cardiolipin modulates the biophysical properties of OMM to allow oligomerized Bax to insert and permeabilize the OMM (Mari et al., 2008
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Weeks 5-8: Increase to 2mg weekly if tolerated
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