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There is significant damage to pancreatic islets due to obesity, as well as metabolic syndrome
Starting above 2mg dramatically increases the probability of nausea severe enough to compromise nutrition and cause early dropout
1) CT 388 has shown a placebo-adjusted WL of 8.5% after 4 weeks in a phase 1 trial [50]
That requires a much closer look
But the picture changes when theyre layered on top of insulin or insulinsecretagogues (e.g., sulfonylureas)
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