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Cleavable linkers mean that the linker can be split during intracellular metabolism, which will produce metabolites containing the cytotoxic agent, which may have part of the linker

A yellow oval in Panel B indicates that the enzyme is affected by estradiol and/or testosterone, and therefore, its activity is different in females than males

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They are considered safe when dosed appropriately and are often recommended alongside other nutritional interventions

Our results not only reveal early metabolomic problems in the motor cortex, but also suggest that maintaining NAD + balance could offer a therapeutic treatment strategy for diseased UMNs with TDP-43 pathology

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