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High doses of ibuprofen taken over extended periods are a leading cause of stomach ulcers and gastrointestinal bleeding

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[PMID: 6402835] PubMed record related to this compound for laboratory literature review

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Signs to look out for include fatigue and lethargy, depression, irritability, headaches, difficulty with balance, decreased cognitive function, constipation, sore or swollen tongue, heart palpitations, mouth ulcers, pins and needles and changes to vision