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Supplemental table 1 provides definitions for inclusion and exclusion criteria and supplemental figure 1 gives an overview of the longitudinal design
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This study revealed a complex metabolic situation determined by insulin and palmitate in CACT-deficient cells, and has provided insight into the functional interactions between CACT, CPT1, malonyl-CoA, and acetyl-carnitine 59
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Additionally, preclinical data has highlighted various positive effects of tirzepatide, including increased survival and proliferation of pancreatic -cells, enhanced insulin synthesis and secretion, and elevated levels of adiponectina key adipokine involved in regulating lipid and glucose metabolism
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