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Other options include hydroxychloroquine, sulfasalazine, and leflunomide

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Another important aspect of their research is that, for this system to function, the correct activity and coordinated action of the various enzymes involved in its complete breakdown are required, highlighting the complexity of these pathways and the ability of tumour cells to adapt and activate alternative metabolic routes

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Future research should focus on designing clinical trials that use fibrosis regression or synovitis reduction as primary endpoints in diseases like osteoarthritis, employing advanced imaging or histological techniques