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Early research in rodents suggested a potential link between GLP-1 receptor agonists and thyroid C-cell tumours (medullary thyroid carcinoma)
A landmark clinical study reporting sustained motor improvements in Parkinsons disease patients treated with the GLP-1 receptor agonist exenatide
Sample Size: 125,474 adults T2DM (61.0% of total sample, n = 76,524) 98.6% (n = 75,434) using GLP-1s as antidiabetic medications 1.4% (n = 1,090) using GLP-1s as antiobesity medications Without T2DM (39.0% of total sample, n = 48,950) 61.8% (n = 30,236) using GLP-1s off-label as antidiabetic medications 38.2% (n = 18,714) using GLP-1s specifically for weight management Data Source: Truveta Data Aggregated electronic health record (EHR) data from 30 U.S
GLP-1 also affects hunger hormones
Peptides Regulating Proliferative Activity and Inflammatory Pathways in the Monocyte/Macrophage THP-1 Cell Line
Protein misfolding and aggregation as a mechanistic link between chronic pain and neurodegenerative diseases
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