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In addition to limited absorption via the IF, the intake of high-dose supplements leads to passive diffusion, i.e., the vitamin can freely enter the bloodstream without IF binding and receptor uptake

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The peak intensities were further assessed by a filtering algorithm in the metabolomics BinBase database using protocols previously described by Fiehn 37 , and data were normalized by a normalization factor (mTIC), which was the sum of all peak heights for all identified metabolites (of only the known compounds)

What adverse effects are expected, and who manages them