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Cell Metab 26:620632

As with other incretin-based therapies, some clients may experience mild gastrointestinal symptoms (nausea, digestive discomfort) typically during the dose-adjustment phase

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Patients with high-sensitivity variants may achieve target weight loss at lower doses and experience fewer side effects, while those with low-sensitivity variants may benefit from faster dose escalation or combination therapies

Adults usually start semaglutide at 0.25 mg once weekly to build tolerance

KDIGO supports the use of GLP-1RAs for people with CKD and T2D and/or obesity