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More growth hormone means enhanced muscle protein synthesis, better fat metabolism, deeper sleep quality, and faster tissue repair

But long-term use also amplifies quality concerns

Some people tell how they now feel comfortable around others, have more energy, and feel full of life

A January study published in JAMA Network Open that included 125,474 patients on the medications found that 46.5% of those with type 2 diabetes and 64.8% of those without stopped taking the drugs within one year

Us Weekly is looking back on her personal transformation, which helped turn her into one of the most recognizable faces in weight loss and overall fitness