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Pharmacokinetic profiles reveal low plasma levels and rapid clearance, confirming the unattainable therapeutic dose using pure compounds or conventional formulations, even with synergistic effects

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Patent protection : GLP-1 medications are still under patent, which means there are no low-cost generic versions yet, and are only sold by the brand-name pharmaceutical company that manufactures them

While preclinical studies offer robust evidence of the neuroprotective and anti-inflammatory properties associated with various phytochemical compounds, confirming their clinical efficacy and safety in human TBI patients is notably lacking, primarily due to the absence of comprehensive clinical data

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