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What the drug-alone data does show is that mice lost fat with no change in food intake, so the effect is not simply appetite suppression

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Other symptoms to follow are headache, face swelling, shortness of breath, a tendency to vomit etc

Accordingly, treatment with the proteasome inhibitor MG132 increased the nuclear accumulation of proIGF-1Eb and proIGF-1Ec, while their cytoplasmic level remained undetectable (Fig

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