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Science 362 , 911917 (2018)
After 18 months of treatment, the proportion of men with testosterone levels in the normal range rose from 53% to 77%.
Patients should be counseled to monitor urine color (pale yellow indicating adequate hydration) and to increase fluid intake during exercise or hot weather
As suggested by the authors, E
For context, in a previous Phase 3 trial of Zepbound, the highest-dose group saw a dropout rate of only 6.2% due to adverse events
However, until now weight reduction induced by modified fasting therapy has not been proved to be effective for long-term weight management
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