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Two: Aib substitutions that prevent DPP-4 degradation and stabilise the peptide's helical structure, and C20 fatty-diacid acylation through a Glu-2xOEG linker that enables reversible albumin binding

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However, after the results of PIONEER 6 (A Trial Investigating the Cardiovascular Safety of Oral Semaglutide in Subjects With Type 2 Diabetes), the FDA approved oral semaglutide