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Human GST A3-3, which, similar to the equine GST A3-3, shows the highest ketosteroid isomerase activity in mammals, has been subjected to analysis at the atomic level based on density functional theory calculations to put forward a refined mechanism for the isomerization of 5-AD (Dourado et al., 2014)

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Within the substantia nigra (largest of four nuclei in the basal ganglia of the midbrain), and some other regions of the brain, synthesis proceeds only to dopamine

H.HamazakiT.OgushiY.HamaR.KobayashiT.et al (2015)