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Preserve Muscle and Bone Mass Through Treatment A similar issue arises with bone and muscle mass in many patients

Interplay between GLP-1 Signaling and Muscle Metabolism GLP-1RAs modulate metabolism through multiple intracellular signaling pathways, including cAMP/PKA, PI3K/Akt, and SIRT1-mediated cascades, influencing glucose uptake, mitochondrial function, and inflammatory responses [82], which may contribute to interactions between GLP-1RA therapy and skeletal muscle metabolism, potentially affecting muscle metabolism and quality

15(02): 301-34 Source: Eli Lilly and Company, (2023)

How Tirzepatide Works Tirzepatides mechanism of action involves stimulating both GLP-1 and GIP receptors