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Constant, non-pulsatile GH rise (as occurs with synthetic GH use) can lead to receptor desensitization, where target tissues become less responsive to growth hormone over time

Reduced glutathione (GSH) is the active antioxidant species that directly scavenges reactive oxygen species and free radicals, while oxidized glutathione (GSSG) is formed when two GSH molecules are linked via a disulfide bond after oxidation

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Access this chapter Subscribe and save Buy Now Tax calculation will be finalised at checkout Purchases are for personal use only Similar content being viewed by others References Azcona C, Preece MA, Rose SJ, Fraser N, Rappaport R, Ranke MB, Savage MO (1999) Growth response to rhIGF-I 80 g/kg twice daily in children with growth hormone insensitivity syndrome: relationship to severity of clinical phenotype