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At week 40, the average change in HbA1c levels from the baseline was -2.40% for the 10-mg tirzepatide group and -2.34% for the 15-mg tirzepatide group, compared to -0.86% for the placebo group

In addition, the inhibition of NLRP3 activation by GLP-1RAs requires regulation of the mitochondrial pathway

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Treatment is typically time-limited, usually up to 2 years

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