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Because the milligram amount is fixed, a lighter body gets more drug exposure per pound: roughly 22% more at 70 kg and about a third less at 120 kg, compared with a 90 kg reference. The dose still comes from response and tolerability, but a lighter person is running a hotter exposure at the same number on the vial
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Quality control for the neurodevelopmental tools All methods that will be used to measure neurodevelopment have been translated, adjusted and/or piloted in previous studies at the current study site
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