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But topical absorption remains variable and may require higher concentrations for systemic effects
This is the straight answer
They are not approved for diagnostic, therapeutic, or recreational use
It has been studied specifically in Achilles tendon, rotator cuff, patellar tendon, and other tendon injury models
The N-terminal hexanoyl cap and specific hydrophobic amino acid sequence (Tyr-Ile-Ahx) were engineered specifically to increase lipophilicity and metabolic stability, allowing Dihexa to cross cell membranes and the blood-brain barrier intact in preclinical models
Liver, spleen, and pancreas are often affected
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